Principal Office
5433 Westheimer Rd., Suite 825
Houston, Texas 77056
FAX (713) 574-4601
*By Appointment Only
601 S. Figueroa St., Suite 4050
Los Angeles, California 90017
FAX (213) 244-1402
Houston Texas Accident Lawyers

Get The Results
You Deserve

Super Lawyers
Mr. Padilla was named a Texas Super Lawyer (Rising Star)(2006) by Thompson Reuters as seen in Texas Monthly Magazine
Houston Personal Injury Lawyers

Get The Results
You Deserve

Super Lawyers
Mr. Padilla was named a Texas Super Lawyer (Rising Star)(2006) by Thompson Reuters as seen in Texas Monthly Magazine
Wrongful Death Attorneys

Get The Results
You Deserve

Super Lawyers
Mr. Padilla was named a Texas Super Lawyer (Rising Star)(2006) by Thompson Reuters as seen in Texas Monthly Magazine

Zofran use for nausea and vomiting during pregnancy linked to birth defects

Medical literature has suggested a link between the use of the prescription drug Zofran (or its generic ondansetron) during pregnancy for nausea or vomiting, and birth defects, particularly cleft palate and heart defects.   Approximately 1 million pregnant American women are exposed to ondansetron every year.

An estimated 80% of pregnant women suffer from nausea and vomiting caused by pregnancy.   Zofran, and its generic ondansetron, are frequently prescribed “off label” by physicians for pregnancy-induced nausea and vomiting even though the drug is not classified as safe in pregnancy by the FDA, and the drug is not labeled for use for nausea and vomiting in pregnancy.

GlaxoSmithKlein Inc. manufactures Zafron, a serotonin 5-HT3 receptor antagonist.  The drug was originally marketed to prevent nausea and vomiting caused by surgery, chemotherapy, and radiation therapy, but not nausea and vomiting due to pregnancy.  In 2007 ondansetron became generic, possibly boosting its sales because of a reduction in cost.

Scientists at Stanford University analyzed plasma samples from 40 pregnant women following a single dose of the drug from umbilical cord blood at delivery, as well as from their babies after birth, concluding that the drug is rapidly transferred to the baby through the placenta and also finding that ondansetron’s effects last longer in the babies than in their  mothers.

Recently, medical literature reported a 2-fold increased risk of heart birth defects with ondansetron taken during pregnancy, and another medical article reported a similar increased risk for cleft palate associated with ondansetron taken in the first trimester of pregnancy.

© Padilla & Rodriguez, L.L.P. All Rights Reserved. Disclaimer | Sitemap

*John M. Padilla is licensed in Texas and California. The firm's other attorneys are licensed in Texas.

Attorney Advertising. The material and information contained on these pages and on any pages linked from these pages are intended to provide general information only and not legal advice. You should consult with an attorney licensed to practice in your jurisdiction before relying upon any of the information presented here. The acts of sending email to this website or viewing information from this website do not create an attorney-client relationship. The listing of verdicts, settlements, and other case results is not a guarantee or prediction of the outcome of any other claims. Law Firm Website Design by Law Promo